منابع مشابه
The interferon inducible gene: Viperin.
The type I interferons (IFNs), IFN-α and -β, are key effector molecules of the immune response to viruses. The anti-viral action of IFNs on virus-infected cells and surrounding tissues is mediated by expression of hundreds of IFN-stimulated genes. Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type ...
متن کاملThe interferon-inducible gene viperin restricts West Nile virus pathogenesis.
Type I interferon (IFN) signaling coordinates an early antiviral program in infected and uninfected cells by inducing IFN-stimulated genes (ISGs) that modulate viral entry, replication, and assembly. However, the specific antiviral functions in vivo of most ISGs remain unknown. Here, we examined the contribution of the ISG viperin to the control of West Nile virus (WNV) in genetically deficient...
متن کاملInducible Expression of Human Gamma Interferon
Background:The premature termination of high producer clones, which will be killed due to cell proliferation and proteins production antagonism, is one of the basic drawback in recombinant proteins technology. Furtheremore, it is supposed some toxic proteins like interferon which we intended to clone and express, inhibit host cells’ proliferation. So, it is necessary to tightly control IFN-γ pr...
متن کاملInterferon-inducible gene expression in dermatomyositis muscle
Gene expression profi ling of peripheral blood or aff ected tissues in patients with autoimmune diseases has revealed important insights into the molecular pathways underlying autoimmunity [1]. Several groups have used gene expression profi ling in an attempt to uncover clues to the pathogenesis of dermatomyositis (DM) (Table 1). Th e most prominent and consistent fi nding of these studies has ...
متن کاملViperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages
Viperin is an antiviral protein that is upregulated by interferons and by ligands for a variety of innate immune receptors. It possesses diverse capabilities and functions in an array of viral infections. Studies have shown that it appears to be particularly important in defence against RNA viruses, such as West Nile, Dengue, and Chikungunya viruses, although the specific mechanisms involved ar...
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ژورنال
عنوان ژورنال: Journal of Interferon & Cytokine Research
سال: 2011
ISSN: 1079-9907,1557-7465
DOI: 10.1089/jir.2010.0127